Job Description
Job Type
Full-time
Description
About TRIANA Biomedicines TRIANA Biomedicines is a Greater Boston biotechnology company building the leading molecular glue discovery platform to regulate disease targets that are difficult to address with any other modality. TRIANA's drug discovery engine is powered by high-resolution structural insights, state-of-the-art AI and computational tools, and bespoke chemical libraries. TRIANA's target-first and rational approach to molecular glue discovery is currently focused on inducing or enhancing the degradation of high-profile cancer targets. The therapeutic approach pioneered by TRIANA has the potential to fundamentally change the paradigm?of small molecule?drug discovery and bring significant therapeutic benefits to patients. TRIANA is a private company with a top-tier investor syndicate.
The Position The Biology and Translational Sciences group at TRIANA Biomedicines is seeking a passionate and independent scientist to help drive pre-portfolio activities to populate an expanding pipeline of high value oncology targets. The qualified candidate will join a growing team of dedicated researchers seeking to deliver on TRIANA's target-first approach to molecular glue discovery.
Responsibilities: - Use genetic and chemical tools to evaluate the protein turnover mechanisms of high value oncology targets
- Optimize proximity-based methods to identify target/effector pairs for glue discovery
- Partner with colleagues in Lead Discovery to design and develop cell-based assays for molecular glue discovery
- Interrogate cellular mechanism of action of novel glues in disease-relevant assay systems
- Record, interpret, and communicate data promptly
- Present data in cross-functional project team meetings
Qualifications: - Solid bench skillset with hands-on experience in molecular and cell biology techniques such as cell culture, CRISPR, RNAi, transfection, lentiviral transduction, immunoprecipitation, immunoblotting, qRT-PCR, and cell proliferation/viability assays
- Solid verbal and writing skills for data documentation, drafting reports and communication to team members
- Team-oriented, flexible, independent, enthusiastic, and collaborative
Education/experience :
- Ph.D. in Cell or Molecular Biology or related discipline with 0-3+ years of post-graduate experience (industry preferred), or BS/MS with 5+ years of industry experience
We welcome applications from skilled individuals whose qualifications may not fit the criteria outlined above.
Our Culture Our Team is our greatest asset at TRIANA. We are proud to work with an integrated group of individuals from an extensive range of backgrounds and experiences. Diversity, Equity, Inclusion and Belonging are important aspects of our culture. We embrace our differences and cultivate an environment that drives better collaboration and innovation by striving to ensure that all coworkers have an ongoing positive experience while being their authentic selves.
Our Values At TRIANA we are
empowered to act. We
dare to create transformative medicines for patients. Our
creativity and
dedication are the glue that unites us in pursuit of our mission.
Thank you for your interest in TRIANA! TRIANA Biomedicines
Job Tags
Full time, Flexible hours,